Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice
Identifieur interne : 000D95 ( Main/Exploration ); précédent : 000D94; suivant : 000D96Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice
Auteurs : Fu-Shi Quan ; Aswani Vunnava ; Richard W. Compans ; Sang-Moo KangSource :
- PLoS ONE [ 1932-6203 ] ; 2010.
Abstract
The 2009 influenza pandemic and shortages in vaccine supplies worldwide underscore the need for new approaches to develop more effective vaccines.
We generated influenza virus-like particles (VLPs) containing proteins derived from the A/California/04/2009 virus, and tested their efficacy as a vaccine in mice. A single intramuscular vaccination with VLPs provided complete protection against lethal challenge with the A/California/04/2009 virus and partial protection against A/PR/8/1934 virus, an antigenically distant human isolate. VLP vaccination induced predominant IgG2a antibody responses, high hemagglutination inhibition (HAI) titers, and recall IgG and IgA antibody responses. HAI titers after VLP vaccination were equivalent to those observed after live virus infection. VLP immune sera also showed HAI responses against diverse geographic pandemic isolates. Notably, a low dose of VLPs could provide protection against lethal infection.
This study demonstrates that VLP vaccination provides highly effective protection against the 2009 pandemic influenza virus. The results indicate that VLPs can be developed into an effective vaccine, which can be rapidly produced and avoid the need to isolate high growth reassortants for egg-based production.
Url:
DOI: 10.1371/journal.pone.0009161
PubMed: 20161790
PubMed Central: 2820088
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice</title><author><name sortKey="Quan, Fu Shi" sort="Quan, Fu Shi" uniqKey="Quan F" first="Fu-Shi" last="Quan">Fu-Shi Quan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Vunnava, Aswani" sort="Vunnava, Aswani" uniqKey="Vunnava A" first="Aswani" last="Vunnava">Aswani Vunnava</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20161790</idno><idno type="pmc">2820088</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2820088</idno><idno type="RBID">PMC:2820088</idno><idno type="doi">10.1371/journal.pone.0009161</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000B00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B00</idno><idno type="wicri:Area/Pmc/Curation">000B00</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000B00</idno><idno type="wicri:Area/Pmc/Checkpoint">000864</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000864</idno><idno type="wicri:Area/Ncbi/Merge">000485</idno><idno type="wicri:Area/Ncbi/Curation">000485</idno><idno type="wicri:Area/Ncbi/Checkpoint">000485</idno><idno type="wicri:Area/Main/Merge">000E01</idno><idno type="wicri:Area/Main/Curation">000D95</idno><idno type="wicri:Area/Main/Exploration">000D95</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Virus-Like Particle Vaccine Protects against 2009 H1N1 Pandemic Influenza Virus in Mice</title><author><name sortKey="Quan, Fu Shi" sort="Quan, Fu Shi" uniqKey="Quan F" first="Fu-Shi" last="Quan">Fu-Shi Quan</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Vunnava, Aswani" sort="Vunnava, Aswani" uniqKey="Vunnava A" first="Aswani" last="Vunnava">Aswani Vunnava</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Compans, Richard W" sort="Compans, Richard W" uniqKey="Compans R" first="Richard W." last="Compans">Richard W. Compans</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The 2009 influenza pandemic and shortages in vaccine supplies worldwide underscore the need for new approaches to develop more effective vaccines.</p></sec><sec><title>Methodology/Principal Findings</title><p>We generated influenza virus-like particles (VLPs) containing proteins derived from the A/California/04/2009 virus, and tested their efficacy as a vaccine in mice. A single intramuscular vaccination with VLPs provided complete protection against lethal challenge with the A/California/04/2009 virus and partial protection against A/PR/8/1934 virus, an antigenically distant human isolate. VLP vaccination induced predominant IgG2a antibody responses, high hemagglutination inhibition (HAI) titers, and recall IgG and IgA antibody responses. HAI titers after VLP vaccination were equivalent to those observed after live virus infection. VLP immune sera also showed HAI responses against diverse geographic pandemic isolates. Notably, a low dose of VLPs could provide protection against lethal infection.</p></sec><sec><title>Conclusion/Significance</title><p>This study demonstrates that VLP vaccination provides highly effective protection against the 2009 pandemic influenza virus. The results indicate that VLPs can be developed into an effective vaccine, which can be rapidly produced and avoid the need to isolate high growth reassortants for egg-based production.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Solovyov, A" uniqKey="Solovyov A">A Solovyov</name></author><author><name sortKey="Palacios, G" uniqKey="Palacios G">G Palacios</name></author><author><name sortKey="Briese, T" uniqKey="Briese T">T Briese</name></author><author><name sortKey="Lipkin, Wi" uniqKey="Lipkin W">WI Lipkin</name></author><author><name sortKey="Rabadan, R" uniqKey="Rabadan R">R Rabadan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dawood, Fs" uniqKey="Dawood F">FS Dawood</name></author><author><name sortKey="Jain, S" uniqKey="Jain S">S Jain</name></author><author><name sortKey="Finelli, L" uniqKey="Finelli L">L Finelli</name></author><author><name sortKey="Shaw, Mw" uniqKey="Shaw 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Compans</name><name sortKey="Kang, Sang Moo" sort="Kang, Sang Moo" uniqKey="Kang S" first="Sang-Moo" last="Kang">Sang-Moo Kang</name><name sortKey="Quan, Fu Shi" sort="Quan, Fu Shi" uniqKey="Quan F" first="Fu-Shi" last="Quan">Fu-Shi Quan</name><name sortKey="Vunnava, Aswani" sort="Vunnava, Aswani" uniqKey="Vunnava A" first="Aswani" last="Vunnava">Aswani Vunnava</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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